Project information
Biomolecular Center
- Project Identification
- LN00A016
- Project Period
- 7/2000 - 12/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Centres
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jaroslav Koča, DrSc.
- Keywords
- Biomolecules, protein, oligonucleotides, NMR spectroscopy, computer simulations and modeling, protein engineering, DNA vaccines, bacteria "quorum systems"
- Cooperating Organization
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Institute of Biophysics
- Responsible person prof. RNDr. Jiří Šponer, DrSc.
- Responsible person doc. RNDr. Ivan Rychlík, Ph.D.
Biomolecular center is designed as an expert laboratory for studiyng the structure and properties of biologically relevant molecules and biopolymers, with main emphasis on proteins and nucleic acid fragments. On the horizontal level the Center will havea strong background in methods for studiing the biomolecules on the atomic level using NMR spectroscopy, molecular modeling and X-ray crystallography with appropriate support of biochemistry and molecular biology. The Center will be able to studythe biomolecular systems in the vertical direction starting with the atomic structure, through their in vitro properties to their function in living cells. From the very beginning, the Center will activelly participate in Ph.D programs (already now 14PhD. students). In the final stage, 25 core scientist will be employed in the Center with a significant support from postdoctoral fellows and PhD. students (2/3 of all coworkers). The group is involved in a large number of international projects.
Publications
Total number of publications: 127
2005
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RNA K-turns-Flexible Ribosomal Motifs:Dynamics, Hydration, Conformations and Biological Relevance
Workshop on Modeling Interactions in Biomolecules II, year: 2005
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Structural basis for the interaction between human milk oligosaccharides and a bacterial protein, Pseudomonas aeruginosa lectin PA-IIL,
Biochemical Journal, year: 2005, volume: 389, edition: 2
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The fucose-binding lectin from Ralstonia solanacearum: a new type of beta-propeller architecture formed by oligomerisation and interacting with fucoside, fucosyllactose and plant xyloglucan
Journal of Biological Chemistry, year: 2005, volume: 280, edition: 30
2004
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1H-13C Correlation Experiments for Detection of Quaternary Carbons in Nucleic Acid Bases
Abstracts of the VIth Central European NMR Symposium, year: 2004
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A Molecular Dynamics Study of the Cyclin-Dependent Kinase-2 (CDK2) with Substrate Peptide (HHASPRK), Inhibition of CDK2 by Phosphorylation
Materials in Structure Chemistry, Biology, Physics and Technology, year: 2004
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A new Ralstonia solanacearum high affinity mannose-binding lectin
Molecular Microbiology, year: 2004, volume: 52, edition: 3
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Activation and Inhibition of Cyclin-Dependent Kinase-2 by Phosphorylation; A Molecular Dynamics Study Reveals the Functional Importance of the Glycine-Rich Loop
Protein Science, year: 2004, volume: 13, edition: 6
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Analysis of Internal Motion from Molecular Dynamics of Major Urinary Protein I
Materials Structure, year: 2004, volume: 11, edition: 1
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Berberine and coptisine free bases
Journal of Molecular Structure, year: 2004, volume: 687, edition: 1-3
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Catalytic strategies of the hepatitis delta virus ribozyme as probed by molecular dynamics simulations.
Year: 2004, type: R&D Presentation