Project information
Biomolecular Center
- Project Identification
- LN00A016
- Project Period
- 7/2000 - 12/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Centres
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jaroslav Koča, DrSc.
- Keywords
- Biomolecules, protein, oligonucleotides, NMR spectroscopy, computer simulations and modeling, protein engineering, DNA vaccines, bacteria "quorum systems"
- Cooperating Organization
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Institute of Biophysics
- Responsible person prof. RNDr. Jiří Šponer, DrSc.
- Responsible person doc. RNDr. Ivan Rychlík, Ph.D.
Biomolecular center is designed as an expert laboratory for studiyng the structure and properties of biologically relevant molecules and biopolymers, with main emphasis on proteins and nucleic acid fragments. On the horizontal level the Center will havea strong background in methods for studiing the biomolecules on the atomic level using NMR spectroscopy, molecular modeling and X-ray crystallography with appropriate support of biochemistry and molecular biology. The Center will be able to studythe biomolecular systems in the vertical direction starting with the atomic structure, through their in vitro properties to their function in living cells. From the very beginning, the Center will activelly participate in Ph.D programs (already now 14PhD. students). In the final stage, 25 core scientist will be employed in the Center with a significant support from postdoctoral fellows and PhD. students (2/3 of all coworkers). The group is involved in a large number of international projects.
Publications
Total number of publications: 127
2001
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Molecular dynamics simulations of solvated UDP-glucose in interaction with Mg cations
European Journal of Biochemistry, year: 2001, volume: 268, edition: 1
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NMR methodology for the study of nucleic acids
Current Opinion in Structural Biology, year: 2001, volume: 11, edition: 3
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Plectin repeats and modules: strategic cysteines and their presumed impact on cytolinker
Bioessays, year: 2001, volume: 23, edition: 11
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Reaction mechanism and stereochemistry of gamma-hexachlorocyclohexane dehydrochlorinase LinA
Journal of Biological Chemistry, year: 2001, volume: 276, edition: 11
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Solution structure of the dodecamer d-(CATGGGCC-CATG)(2) is B-DNA. Experimental and molecular dynamics study
Journal of Biomolecular Structure and Dynamics, year: 2001, volume: 19, edition: 1
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Structural dynamics and cation interactions of DNA quadruplex molecules containing mixed guanine/cytosine quartets revealed by large-scale MD simulations
Journal of the American Chemical Society, year: 2001, volume: 123, edition: 14
2000
-
Effect of Cation Concentration on Molecular Dynamics Simulations of UDP-glucose.
Molecular Simulations, year: 2000, volume: 24, edition: 1