Project information
Molecular mechanisms of the cell proliferation and differentiation
- Project Identification
- GD204/08/H054
- Project Period
- 1/2008 - 12/2011
- Investor / Pogramme / Project type
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Czech Science Foundation
- Doctor grants
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jan Šmarda, CSc.
- prof. RNDr. Jiří Fajkus, CSc.
- doc. RNDr. Lenka Fajkusová, CSc.
- doc. RNDr. Jan Hejátko, Ph.D.
- doc. Mgr. Ctirad Hofr, Ph.D.
- Mgr. Jakub Horák, Dr. rer. nat.
- RNDr. Lubomír Janda, Ph.D.
- doc. RNDr. Jaromír Marek, Ph.D.
- doc. Mgr. Jan Paleček, Dr. rer. nat.
- prof. RNDr. Jana Šmardová, CSc.
- prof. RNDr. Renata Veselská, Ph.D., M.Sc.
- Mgr. Pavlína Zatloukalová, Ph.D.
- prof. RNDr. Zbyněk Zdráhal, Dr.
- Other MU Faculty/Unit
- Faculty of Informatics
- Keywords
- regulation of cell proliferation and differentiation, genomics and proteomics, plant, animal and microbial models, bioinformatics
Plants and animals evolved significantly different strategies of regulation of the cell proliferation and differentiation. Identification and comparison of molecular mechanisms driving those different strategies in plants, animals and microorganisms might contribute to the identification of their common principles. The project is based on collaboration of laboratories involved in the study of the processes of the cell proliferation and differentiation in those different model organisms including human beings. Collaboration of the laboratories with expertise in (i) molecular plant physiology, (ii) molecular mechanisms maintaining the genome stability, (iii) proliferation, differentiation and programmed cell death of cancer cells and (iv) bioinformatics will result into a multidisciplinary, while still functional team that will guarantee successful solution of scheduled tasks. Participation of multiple, recently collaborating laboratories including Core lab will allow effective employment of high-throughput instrumentation in the planned genomics and proteomics approaches.
Publications
Total number of publications: 87
2010
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The use of Cox-2 and PPAR gamma signaling in anti-cancer therapies (Review)
Experimental and Therapeutic Medicine, year: 2010, volume: 1, edition: 1
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Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells
Year: 2010, type: Conference abstract
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Wedelolakton inhibuje proliferaci a indukuje diferenciaci a/nebo apoptózu buněk karcinomu prsu
Year: 2010, type: Conference abstract
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Ztráta kopie genu pro EGFR u pacienta s multiformním glioblastomem: případová studie a analýza derivované linie.
Year: 2010, type: Conference abstract
2009
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Application of fluorescence anisotropy to monitor protein binding to telomeric DNA
Year: 2009, type: Conference abstract
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Aspergillus fumigatus host-interacting proteins - potential therapeutic targets
Year: 2009, type: Conference abstract
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Cancer stem cell markers in selected childhood tumors of mesenchymal origin.
International Journal of Mol. Medicine 24 (Sup. 1) - the 14th World Congress on Advances in Oncology and the 12th International Symposium on Molecular Medicine., year: 2009
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c-Myb prevents apoptosis of colon carcinoma cells in Cox-2-independent manner
International Journal of Molecular Medicine, year: 2009
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c-Myb prevents apoptosis of colon carcinoma cells: modulating effects of cyclooxygenase 2?
Year: 2009, type: Conference abstract
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Complex analysis of cyclin D1 expression in mantle cell lymphoma: two cyclin D1-negative cases detected
American journal of clinical pathology : official publication the American Society of Clinical Pathologists., year: 2009, volume: 62, edition: 10, DOI