Project information
Molecular mechanisms of the cell proliferation and differentiation
- Project Identification
- GD204/08/H054
- Project Period
- 1/2008 - 12/2011
- Investor / Pogramme / Project type
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Czech Science Foundation
- Doctor grants
- MU Faculty or unit
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Faculty of Science
- prof. RNDr. Jan Šmarda, CSc.
- prof. RNDr. Jiří Fajkus, CSc.
- doc. RNDr. Lenka Fajkusová, CSc.
- doc. RNDr. Jan Hejátko, Ph.D.
- doc. Mgr. Ctirad Hofr, Ph.D.
- Mgr. Jakub Horák, Dr. rer. nat.
- RNDr. Lubomír Janda, Ph.D.
- doc. RNDr. Jaromír Marek, Ph.D.
- doc. Mgr. Jan Paleček, Dr. rer. nat.
- prof. RNDr. Jana Šmardová, CSc.
- prof. RNDr. Renata Veselská, Ph.D., M.Sc.
- Mgr. Pavlína Zatloukalová, Ph.D.
- prof. RNDr. Zbyněk Zdráhal, Dr.
- Other MU Faculty/Unit
- Faculty of Informatics
- Keywords
- regulation of cell proliferation and differentiation, genomics and proteomics, plant, animal and microbial models, bioinformatics
Plants and animals evolved significantly different strategies of regulation of the cell proliferation and differentiation. Identification and comparison of molecular mechanisms driving those different strategies in plants, animals and microorganisms might contribute to the identification of their common principles. The project is based on collaboration of laboratories involved in the study of the processes of the cell proliferation and differentiation in those different model organisms including human beings. Collaboration of the laboratories with expertise in (i) molecular plant physiology, (ii) molecular mechanisms maintaining the genome stability, (iii) proliferation, differentiation and programmed cell death of cancer cells and (iv) bioinformatics will result into a multidisciplinary, while still functional team that will guarantee successful solution of scheduled tasks. Participation of multiple, recently collaborating laboratories including Core lab will allow effective employment of high-throughput instrumentation in the planned genomics and proteomics approaches.
Publications
Total number of publications: 87
2008
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Expresní profily vybraných transkripčních faktorů v průběhu osteoklastové diferenciace
XII. Pracovní setkání biochemiků a molekulárních biologů. Sborník abstraktů., year: 2008
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Functional cross-talk of integrin b3 and AP-1 in differentiating osteoclasts and dendritic cells.
Book of Abstracts, year: 2008
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Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana
Phytochemistry, year: 2008, volume: 69, edition: 9
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Funkční interakce integrinu beta 3 a transkripčních faktorů c-jun a c-fos během diferenciace buněk RAW264.7
Year: 2008, type: Conference abstract
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Identifikace markerů nádorových kmenových buněk v osteosarkomech.
Sborník abstraktů a přednášek - 18. konference dětských hematologů a onkologů České a Slovenské republiky, year: 2008
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Isolation of RNA from brain tumors for use in real-time PCR
Year: 2008, type:
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Modulation of the antineoplastic effect of retinoids in neuroblastoma and medulloblastoma cell lines.
XIX. Biologické dny - Biologický výzkum pro lidské zdraví. Program a sborník abstrakt., year: 2008
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Nestin expression in osteosarcomas and derivation of nestin/CD133 positive osteosarcoma cell lines.
BMC Cancer, year: 2008, volume: 8, edition: 300
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Proteiny rodiny TGFbeta sekretované prostatickými nádorovými buňkami ovlivňují diferenciaci osteoklastů
Zborník abstraktov, year: 2008
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Regulation of osteoclast differentiation by the TGFbeta proteins secreted by prostate cancer
Stem cells, cancer and aging, year: 2008