Project information
Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus
- Project Identification
- NU22-02-00348
- Project Period
- 5/2022 - 12/2025
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Ministry of Health Research Programme 2020 - 2026
- Subprogram 1 - standard
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Cooperating Organization
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University Hospital Brno-Bohunice
- Responsible person doc. MUDr. Tomáš Novotný, Ph.D.
Funkční hodnocení genetických variant u případů klinicky „skutečné“ idiopatické fibrilace komor: in vitro a in silico modelování s cílem odhalit arytmogenní mechanismus
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 37
2024
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Pacient-specifické kardiomyocyty s variantou Y4734C-RYR2: Ca2+ přechody v kontrole a po aplikaci kofeinu
Year: 2024, type: Conference abstract
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ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE
ENGINEERING MECHANICS: 30th INTERNATIONAL CONFERENCE May 14 – 16, 2024, Milovy, Czech Republic, year: 2024
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Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model
Scientific Reports, year: 2024, volume: 14, edition: 27399, DOI
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Spontaneous electrical activity of hiPSC-CM from a patient with idiopathic ventricular fibrillation under possibly arrhythmogenic conditions
Year: 2024, type: Appeared in Conference without Proceedings
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Spontaneous electrical activity of patient-specific cardiomyocytes with a variant in the RYR2 gene recorded by multielectrode array technique
Year: 2024, type: Conference abstract
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The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting
Scientific Reports, year: 2024, volume: 14, edition: 1, DOI
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Variants in the hERG channel associated with idiopathic ventricular fibrillation: clinical, genetic, and functional analysis
Year: 2024, type:
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Vliv varianty S1021Qfs*98 v genu hERG na aktivaci a deaktivaci proteinu Kv11.1
Year: 2024, type: Conference abstract
2023
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Functional consequences of different distribution of NCX and PMCA between t-tubular and surface membranes in a model of the human ventricular cardiomyocyte
Year: 2023, type: Conference abstract
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Funkční analýza varianty S1021Qfs*98 v kanálu KCNH2 (genu hERG)
Year: 2023, type: Conference abstract