Project information
Principles and consequences of changes in drug metabolism evoked by imunological factors
- Project Identification
- IZ3430
- Project Period
- 1/1996 - 1/1998
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Problems of Separate Medical Branches
- MU Faculty or unit
- Faculty of Medicine
Projek se zabývá vztahy mezi imunologickými faktory a metabolismem léčiv. Na preklinické a molekulární úrovni budou studovány mechanismy změn vyvolaných imunostimulátory a imunosupresivy v oxidativním a acetilačním metabolismu.
Publications
Total number of publications: 6
1998
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Abolition of LPS-evoked changes in the procainamide acetylation in the isolated perfused rat liver by iNOS inhibitor aminoguanidine.
Naunyn-Schmiedebergs Arch. Pharmacol, year: 1998, volume: 358, edition: 1(Supl.2)
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Influence of pretreatment with immunosuppressants on O-demethylation of dextromethorphan in isolated perfused rat liver
Experimental and Toxicologic Pathology, year: 1998, volume: 50, edition: 2
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The influence of LPS in vitro on N-acetylation of procainamide in isolated perfused rat liver.
Naunyn-Schmiedebergs Arch. Pharmacol, year: 1998, volume: 358, edition: 1(Supl.2)
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Účinek imunosupresiv na metabolismus dextrometorfanu v izolovaných játrech potkana.
Československá fyziologie, year: 1998, volume: 47, edition: 4
1997
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Influence of NO-synthase inhibition on the LPS-evoked chang s in the pharmacokinetics of procainamide in the rat
Voj. zdrav. listy, year: 1997, volume: 66, edition: 2.
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Vliv inhibice NO-syntázy na změny acetylační kapacity izolovaných jater potkana vyvolané lipopolysacharidem
Zborník súhrnov - 47. Farmakologické dni, year: 1997