Project information
CZ-OPENSCREEN: National Infrastructure for Chemical Biology
(CZ-OPENSCREEN)
- Project Identification
- LM2015063
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
- Faculty of Science
- Cooperating Organization
-
Institute of Molecular Genetics of the ASCR, v. v. i.
- Responsible person RNDr. Petr Bartůněk, CSc.
Prague Institute of Chemical Technology
The aim of the project „CZ-‐OPENSCREEN: National infrastructure for chemical
biology” is to operate the state-‐of-‐the-‐art infrastructure for basic and applied
research in the fields of chemical biology and genetics and provide Open Access to users. It will serve as the National node of the pan-European ESFRI infrastructure EU-‐OPENSCREEN, providing trans-‐national access to the
Screening platform and to the European Chemical Biology Library. The mission
of CZ-‐OPENSREEN is to identify new molecular probes/tools for research and
new potential therapeutics.
Publications
Total number of publications: 31
2018
-
Preparation of 3,4-Substituted-5-Aminopyrazoles and 4 Substituted-2-Aminothiazoles
The Journal of Organic Chemistry, year: 2018, volume: roč. 83, edition: č. 24, DOI
-
Pyrazolotriazines as inhibitors of nucleases
Publisher: Japan Patent Office, state: Japan, patent's number: JP 6313906, year: 2018
-
Pyrazolotriazines as inhibitors of nucleases
Publisher: USPTO, state: United States of America, patent's number: US 9969741 B2, year: 2018
2017
-
A Concise Synthesis of Forskolin
Angewandte Chemie International Edition, year: 2017, volume: 2017, edition: 56, DOI
-
BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors
Tumor Biology, year: 2017, volume: 2017, edition: October, DOI
-
Diastereoselective Flexible Synthesis of Carbocyclic C Nucleosides
The Journal of Organic Chemistry, year: 2017, volume: 82, edition: 7, DOI
-
Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines
European Journal of Medicinal Chemistry, year: 2017, volume: 126, edition: January, DOI
-
Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells
Neoplasia, year: 2017, volume: 19, edition: 10, DOI
-
Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles
ChemPhysChem, year: 2017, volume: 18, edition: 7, DOI
-
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation
Molecular Cancer Therapeutics, year: 2017, volume: 16, edition: 9, DOI