Project information
Environment - carcinogenesis - oncology
- Project Identification
- MSM 141100003
- Project Period
- 1/1999 - 1/2004
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Keywords
- environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy
The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.
Publications
Total number of publications: 670
2000
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Advances and trends in environmental chemistry - the case of persistent, bioaccumulative nad toxic compounds (PBTs) in the environment
Chemické listy, year: 2000, volume: 94, edition: 6
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Analýza a interpretace křivek dávka - odpověď : univerzální problém ekotoxikologie a prediktivní onkologie
Hodnocení rizik pro životní prostředí - ERA 2000, year: 2000
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Analýza chemosensitivity buněčných linií maligního původua primokultur lidského maligního melanomu na panel protinádorových chemoterapeutik.
Klinická onkologie, year: 2000, volume: 13, edition: zvl.č. 2
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Automated Hot Solvent Extraction of Atrazine and Its Degradation Products from Soil Samples
Sborník konference Pokroky v chromatografii a elektroforéze 2000, year: 2000
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Bioterapie nádorů
Klinická onkológia a rádioterapia, year: 2000, number of pages: 11 s.
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Cesty ke snižování úmrtnosti na karcinom prsu
Medica revue, year: 2000, volume: 7, edition: 4
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Cyanobacterie a hepatotoxické microcystiny ve vodárenských nádržích v ČR
Aktuální otázky vodárenské biologie, year: 2000
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Cyanotoxiny - zdraví obyvatel nebo zdraví ekosystémů ?
Hodnocení rizik pro životní prostředí - ERA 2000, year: 2000
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Ecological risk assessment - approaches and trends
7th Regional meeting of the Central and East European section of SECOTOX - Contributed papers, year: 2000
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Edrekolomab v adjuvantní imunoterapii kolorektálního kacinomu
Monoklonální protilátky v onkologii, year: 2000, number of pages: 11 s.