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Project information
Environment - carcinogenesis - oncology

Project Identification
MSM 141100003
Project Period
1/1999 - 1/2004
Investor / Pogramme / Project type
Ministry of Education, Youth and Sports of the CR
  • Research Intents
MU Faculty or unit
Faculty of Medicine
Keywords
environmental pollutants; genotoxic agents; mechanisms of genomic and extragenomic carcinogenesis; predictive bioparameters ; optimization of oncological therapy

The aim of this multidisciplinary project is to contribute to the research of the mechanisms of carcinogenesis with a special interest devoted to reduction of risks from environmental pollutants and genotoxic effects of therapeutic agents. The investigation of effects of persistent organic pollutants and other genotoxic compounds on induction and development of malignant tumors. The special interest will be paid also to the process of extragenomic carcinogenesis. Biomathematical analysis of risks of genotoxicity in their real proportions, which couples the data from basic environmental reasearch, toxicology, experimental biology and clinical oncology. Multivariate mathematical analysis of oncological bioparameters directed mainly to prediction of the efficacy of treatment in different types of tumors and optimization of therapeutic regimens.

Publications

Total number of publications: 670

2005

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