Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1210
2009
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Diversity of prophages in dominant Staphylococcus aureus> clonal lineages
Journal of Bacteriology, year: 2009, volume: 191, edition: 11
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Effects of magnesium binding and beryllofluoridation on a component of the cytokinin signaling pathway studied by nuclear magnetic resonance
Year: 2009, type: Conference abstract
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Evolution of protein modularity
Current Opinion in Structural Biology, year: 2009, volume: 19, edition: 3
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Evolutionary response of telomeric proteins to the loss of ancestral telomeres in Solanaceae
XIII. Setkání biochemiků a molekulárních biologů, year: 2009
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Exceptional fluorescence properties of some quaternary benzo[c]phenanthridine alkaloids.
Book of Abstract of Conference of Functional Molecules from Natural Sources, year: 2009
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EXPRESE TRANSKRIPČNÍHO FAKTORU NFAT1 ZVYŠUJE CITLIVOST MONOBLASTŮ BM2 KE KYSELINĚ RETINOVÉ
XIII. Setkání biochemiků a molekulárních biologů, year: 2009
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Expression profiling of neuroblastoma cell lines after combined treatment with all-trans retinoic acid and LOX/COX inhibitors
Genes and Cancer - 26th Meeting, year: 2009
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Extraction of PCR-ready DNA from Staphylococcus aureus bacteriophages using carboxyl functionalized magnetic nonporous microspheres
Journal of Chromatography B, year: 2009, volume: 877, edition: 7
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Fibroblast growth factor inhibits interferon gama-STAT1 and interleukin 6-STAT3 signaling in chondrocytes
Cellular Signalling, year: 2009, volume: 21, edition: 1, DOI
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Functionalised magnetic microsphereswith hydrophilic properties for molecular diagnostic applications
FOOD RESEARCH INTERNATIONAL, year: 2009, volume: 42, edition: 4