Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1210
2010
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Using the FISH method for an identification of genetic alterations in cervical carcinoma ane cervical intraepithelial neoplasia: gain of human telomerase gene (hTERC)
Year: 2010, type: Conference abstract
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Vlastnosti kmenů Staphylococcus aureus způsobujících abscedující nekrotizující pneumonie v ČR
Year: 2010, type: Conference abstract
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Výskyt genů kódujících bakteriociny v kmenech E. coli izolovaných z klinického materiálu.
Year: 2010, type: Conference abstract
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Vývoj nových DNA markerů pro geny odolnosti k padlí travnímu u ječmene
XIV. Pracovní setkání biochemiků a molekulárních biologů, year: 2010
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Wedelolactone suppresses growth and induces differentiation and apoptosis of breast cancer cells
Year: 2010, type: Conference abstract
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Wedelolakton inhibuje proliferaci a indukuje diferenciaci a/nebo apoptózu buněk karcinomu prsu
Year: 2010, type: Conference abstract
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Whole genome fingerprinting of 8 strains from the genus Treponema.
Year: 2010, type: Conference abstract
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Ztráta kopie genu pro EGFR u pacienta s multiformním glioblastomem: případová studie a analýza derivované linie.
Year: 2010, type: Conference abstract
2009
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4th myeloma and 2nd immunotherapy workshop
Year: 2009, type: Workshop
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A bicontinental origin of polyploid Australian/New Zealand Lepidium species (Brassicaceae)? Evidence from genomic in situ hybridization
Annals of Botany, year: 2009, volume: 104, edition: 4