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Project information
Enhancement of G-CSF action by adenosine signalling: testing of its potential clinical use in murine models

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Project Identification
GA306/99/0027
Project Period
1/1999 - 1/2001
Investor / Pogramme / Project type
Czech Science Foundation
  • Standard Projects
MU Faculty or unit
Faculty of Medicine
Cooperating Organization
Institute of Biophysics
  • Responsible person doc. MUDr. Michal Hofer, CSc.

Previous original findings of the applicants have demonstrated synergistic effects of granulocyte colony-stimulating factor (G-CSF) and drugs elevating extracellular adenosine (dipyridamole, AMP). Potentiation of proliferation and differentiation in the granulopoietic compartment has been shown in experiments on both normal and gamma-irradiated mice. The project submitted intends to extend these findings with respect to the clinical use of G-CSF. Interactions of G-CSF with dipyridamole and AMP will be s tudied in the following two experimental situations: (1) the use of G-CSF for stimulation of granulocyte production in neutropenic states evoked by cytotoxic drugs and (2) the use of G-CSF for mobilization of circulating hematopoietic progenitor cells.

Publications

Total number of publications: 6

2002

2001

2000

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