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Project information
Specific ion effects for proteins in solutions and related biologically relevant systems

Information

This project doesn't include Faculty of Medicine. It includes Faculty of Science. Official project website can be found on muni.cz.
Investor logo
Project Identification
GA203/08/0114
Project Period
1/2008 - 12/2012
Investor / Pogramme / Project type
Czech Science Foundation
  • Standard Projects
MU Faculty or unit
Faculty of Science
Keywords
salt ions, enzymatic reactions, membranes, molecular dynamics, fluorescence spectroscopy
Cooperating Organization
J. Heyrovský Institute of Physical Chemistry of the ASCR, v. v. i.
  • Responsible person doc. Martin Hof, Dr.
Institute of Organic Chemistry and Biochemistry of the ASCR, v. v. i.
  • Responsible person Doc. Mgr. Pavel Jungwirth, CSc.
University of South Bohemia České Budějovice
  • Responsible person Doc. RNDr. Rüdiger Ettrich, Ph.D.

The mechanism of hydration of ions and interaction of ions with biomolecules play an important role in many natural and biotechnological processes. We plan within this proposal to combine computational and experimental tools with the aim to obtain a fundamental molecular understanding of these reactions. We will focus on ion specific interactions with proteins in aqueous and non-aqueous solutions and at lipid membranes. Carefully designed molecular dynamics simulations and experiments will allow us in the end to formulate general rules for interactions of biologically relevant ions with solvated proteins and membranes, as well as rationalize ion effects on the activity of enzymes.

Publications

Total number of publications: 37

2009

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