Project information
Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine
- Project Identification
- LC06035
- Project Period
- 3/2006 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Basic Research Center
- MU Faculty or unit
- Faculty of Science
- Keywords
- nukleové kyseliny, proteiny, karcinogeny, léčiva, poškození DNA, hybridizace DNA, interakce DNA-protein, nádorové supresory, amyloidní proteiny, mutantní proteiny, denaturace, agregace, elektrochemie, separace, kapilární elektroforéza, hmotová spektromet
- Cooperating Organization
-
Institute of Biophysics
Charles University
University of Pardubice
Masaryk Memorial Cancer Institute Brno
After completion of the human genome project, there is demand for simple and inexpensive methods enabling analysis of details of individuals' genomes. The contemporary world science is oriented towards utilization of electrochemical DNA detection in thisanalysis. DNA electroactivity was discovered at the Institute of Biophysics in Brno. Laboratories of this Institute belong to the world elite in this field for more than four decades. In the partner laboratories, a considerable progress has been attainedin the research of electrochemical DNA sensors as well as in analysis of proteins and other substances in recent years. This project is based on the existing results and it is oriented towards advanced studies of the properties of biomacromolecules andt heir interactions with surfaces, especially electrodes, and towards research of intermolecular interactions of DNA and/or proteins important in severe disorders (cancer, Parkinson's or Alzheimer's disease). On the basis of electrochemistry, miniaturiza
Publications
Total number of publications: 228
2008
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INTERCALATION OF BENZOPHENANTRIDINE ALKALOIDS TO DOUBLE-STRANDED OLIGONUCLEOTIDES
XIII Internatinal Symposium on Luminescence Spectroscopy-Final program and Abstracts book, year: 2008
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KOMPLEXNÍ INOVACE A MODERNIZACE LABORATORNÍCH CVIČENÍ Z FYZIKÁLNÍ CHEMIE
VIII. pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků, year: 2008
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Microanalysis of Purine Aminoderivatives by Stripping and Elimination Voltammetry at Carbon Electrodes
Electrochemistry of Nucleic Acids and Proteins. Book of Abstracts, year: 2008
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Možnosti využití časově rozlišené fluorescence při studiu oligonukleotidů
Sborník příspěvků, VIII. Pracovní setkání fyzikálních chemiků a elektrochemiků, year: 2008
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Multidetection platform for microcolumn separation of proteins and peptides
Year: 2008, type:
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New Options in Light Emitting Diode-Based Photometric and Fluorimetric Detection Systems for Capillary Electrophoresis and Microfluidic Chips
Vitamins 2008 Nutrition and Diagnostics, year: 2008
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Nové možnosti detekce proteinu p16
Year: 2008, type: Conference abstract
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Off-line capillary electrophoresis laser ablation inductively coupled plasma mass spectrometry
Year: 2008, type: R&D Presentation
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Off-line capillary electrophoresis laser ablation inductively coupled plasma mass spectrometry for elemental speciation
Year: 2008, type: Conference abstract
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Off-line coupling of capillary electrophoresis to inductively coupled plasma mass spectrometry for elemental speciation
Year: 2008, type: Conference abstract