MUDr. Roman Hakl, Ph.D.

2024

• PLAUR alternative splicing in patients with different severity of hereditary angioedema (HAE)

  BAROŠ Jan HAKL Roman BALLONOVÁ Lucie KULÍŠKOVÁ Petra SLANINA Peter ŠTÍCHOVÁ Julie VLKOVÁ Marcela SOUČEK Přemysl FREIBERGER Tomáš LITZMAN Jiří

  Conference abstract

  Year: 2024, type: Conference abstract

• The Chronic Angioedema Registry (CARE): Rationale, Methods and Implementation

  BUTTGEREIT T AULENBACHER F GUTSCHE A KOLKHIR P WELLER K C Vera Ayala MAGERL M FARKAS H GRUMACH A S AYGOEREN-PUERSUEN E BARA N BEN-SHOSHAN M BERNSTEIN J BETSCHEL S BOUILLET L CABALLERO T CANCIAN M CASTALDO A J CIMBOLLEK S COHN D M CRAIG T FOMINA D GELINCIK A GRIVCHEVA-PANOVSKA V JINDAL A KATELARIS C KESSEL A KINACIYAN T LONGHURST H J MARTINEZ-SAGUER I RIEDL M SCHOEFFL C STAUBACH P ZANICHELLI A ZHI Y H Balle Boysen FOK J S LI P H HAKL Roman HIDE M PETER J MAURER M

  Article in Periodical

  CLINICAL AND EXPERIMENTAL ALLERGY, year: 2024, DOI

• Timing of Onset of Garadacimab for Preventing Hereditary Angioedema Attacks

  STAUBACH Petra TACHDJIAN Raffi LI H. Henry HAKL Roman AYGÖREN-PÜRSÜN Emel WIEMAN Lolis JOHN-PHILIP Lawo CRAIG Timothy J.

  Article in Periodical

  Clinical & Experimental Allergy, year: 2024, DOI

2023

• An investigational oral plasma kallikrein inhibitor for on-demand treatment of hereditary angioedema: atwo-part, randomised, double-blind, placebo-controlled, crossover phase 2 trial

  AYGOEREN-PUERSUEN Emel ZANICHELLI Andrea COHN Danny M CANCIAN Mauro HAKL Roman KINACIYAN Tamar MAGERL Markus MARTINEZ-SAGUER Inmaculada STOBIECKI Marcin FARKAS Henriette KIANI-ALIKHAN Sorena GRIVCHEVA-PANOVSKA Vesna BERNSTEIN Jonathan A LI H Henry LONGHURST Hilary J AUDHYA Paul K SMITH Michael YEA Christopher M MAETZEL Andreas LEE Daniel K FEENER Edward P GOWER Richard LUMRY William R BANERJI Aleena RIEDL Marc A MAURER Marcus

  Article in Periodical

  Lancet, year: 2023, volume: 401, edition: 10375, DOI

• Myeloid lineage cells evince distinct steady-state level of certain gene groups in dependence on hereditary angioedema severity

  BALLONOVÁ Lucie SOUČEK Přemysl SLANINA Peter RÉBLOVÁ Kamila ZAPLETAL Ondřej VLKOVÁ Marcela HAKL Roman BÍLY Viktor GROMBIŘÍKOVÁ Hana SVOBODOVÁ Eliška KULÍŠKOVÁ Petra ŠTÍCHOVÁ Julie SOBOTKOVÁ Marta RADANA Zachová HANZLÍKOVÁ Jana VACHOVÁ Martina KRÁLÍČKOVÁ Pavlína KRČMOVÁ Irena JESEŇÁK Miloš FREIBERGER Tomáš

  Article in Periodical

  FRONTIERS IN GENETICS, year: 2023, volume: 14, edition: July 2023, DOI

• PLAUR splicing pattern in hereditary angioedema patients' monocytes and macrophages

  BALLONOVÁ Lucie KULÍŠKOVÁ Petra SLANINA Peter ŠTÍCHOVÁ Julie VLKOVÁ Marcela HAKL Roman LITZMAN Jiří SOUČEK Přemysl FREIBERGER Tomáš

  Article in Periodical

  Molecular Biology Reports, year: 2023, volume: 50, edition: 6, DOI

• Porovnanie diferenciácie a aktivácie monocytov a sledovanie funkčných zmien mitochondrií monocytov prietokovou cytometriou pred analýzou expresie génu PLAUR

  SLANINA Peter ŠTÍCHOVÁ Julie KULÍŠKOVÁ Petra BALLONOVÁ Lucie BAROŠ Jan LITZMAN Jiří VLKOVÁ Marcela SOUČEK Přemysl FREIBERGER Tomáš HAKL Roman

  Conference abstract

  Year: 2023, type: Conference abstract

• Systematic Approach Revealed SERPING1 Splicing-Affecting Variants to be Highly Represented in the Czech National HAE Cohort

  GROMBIŘÍKOVÁ Hana BÍLY Viktor SOUČEK Přemysl KRAMÁREK Michal HAKL Roman BALLONOVÁ Lucie RAVCUKOVA Barbora RICNA Dita KOŽENÁ Karolína KRATOCHVÍLOVÁ Lucie SOBOTKOVA Marta ZACHOVA Radana KUKLÍNEK Pavel KRALICKOVA Pavlina KRCMOVA Irena HANZLIKOVA Jana VACHOVA Martina KRYSTUFKOVA Olga DANKOVA Eva JESENAK Milos NOVACKOVA Martina SVOBODA Michal LITZMAN Jiří FREIBERGER Tomáš

  Article in Periodical

  Journal of Clinical Immunology, year: 2023, volume: 43, edition: 8, DOI

2022

• Different patterns of immune system activation in hereditary angioedema based on disease severity

  BALLONOVÁ Lucie SOUČEK Přemysl HAKL Roman SLANINA Peter VLKOVÁ Marcela SOBOTKOVÁ Marta KRÁLÍČKOVÁ Pavlína KRČMOVÁ I. HANZLÍKOVÁ Jana VACHOVÁ M. JESENÁK Miloš GROMBIŘÍKOVÁ Hana RÉBLOVÁ Kamila BÍLY Viktor ZAPLETAL Ondřej FREIBERGER Tomáš

  Conference abstract

  Year: 2022, type: Conference abstract

• OPTIMALIZÁCIA IN VITRO DIFERENCIÁCIE A AKTIVÁCIE MONOCYTOV PRED ANALÝZOU EXPRESIE GÉNU PLAUR

  SLANINA Peter ŠTÍCHOVÁ Julie KULÍŠKOVÁ Petra BALLONOVÁ Lucie BAROŠ Jan LITZMAN Jiří VLKOVÁ Marcela SOUČEK Přemysl FREIBERGER Tomáš HAKL Roman

  Conference abstract

  Year: 2022, type: Conference abstract