PREPARATION OF APOFERRITIN SILVER PHOSPHATE NANOPARTICLES

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Authors	KOPEL Pavel DOSPIVOVÁ Dana HYNEK David HUBÁLEK Jaromír TRNKOVÁ Libuše STIBOROVÁ Marie ECKSCHLAGER Tomáš ADAM Vojtěch KIZEK René
Year of publication	2012
Type	Article in Proceedings
Conference	XII. Pracovní setkání fyzikálních chemiků a elektrochemiků. Sborník příspěvků.
MU Faculty or unit	Faculty of Science
Citation
Field	Physical chemistry and theoretical chemistry
Keywords	MRSA;silver;nanoparticles
Description	Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for several difficult-to-treat infections in humans. Therefore, it is not surprising that other ways how to treat these bacteria are looked for. Silver(I) ions and silver nanoparticles exhibited the highest antimicrobial activity against MRSA but their transporting to the place of needs and in situ determination is an issue. We studied the encapsulation of silver(I) ions into apoferritin as a possible way for transportation of these ions. Primarily we optimized the encapsulation conditions to prepare the most stable complex, which was subsequently utilized for treatment of S. aureus. Based on the results obtained it can be concluded that silver(I) ions remain enclosed in the apoferritin structure until decomposition of apoferritin by bacterial enzymatic apparatus occurs.