Low-level copy number changes of MYC genes have a prognostic impact in medulloblastoma

• Authors: ZITTERBART Karel; FILKOVÁ Hana; TOMÁŠIKOVÁ Lenka; NEČESALOVÁ Eva; ZAMBO Iva; KANTOROVÁ Dagmar; SLÁMOVÁ Iva; VRANOVÁ Vladimíra; ŽEŽULKOVÁ Dita; PEŠÁKOVÁ Martina; PAVELKA Zdeněk; VESELSKÁ Renata; KUGLÍK Petr; ŠTĚRBA Jaroslav
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Journal of Neuro-Oncology
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s11060-010-0289-3
• Field: Oncology and hematology
• Keywords: medulloblastoma; amplification; gain; MYCN; MYCC; I-FISH
• Description: Analysis of a cohort of 29 medulloblastoma patients has clearly shown that copy number increases of MYC genes (MYCC, MYCN)are associated with lowered event-free survival and overall survival in MB. In the case of MYCN, this negative correlation was statistically significant.