Overdiagnosis in breast cancer screening programme in the Czech Republic
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| Year of publication | 2010 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | Background: There were 1,611,582 examinations performed in 1,067,836 women attending organized breast cancer screening programme in Czech Republic during period 2002-2007. Total of 7,835 cases of breast cancer were detected. Objective: To estimate the extent of overdiagnosis for different age groups. Methods: Overdiagnosis of ductal carcinoma in situ (DCIS) only was assumed. Certain proportion of DCIS is non-progressive and represents the overdiagnosed tumours. Markov models with variable number of states were used. Simultaneous estimation of lambda1 (transition rate to preclinical screen-detectable phase, where no signs of the disease are present, but it could be detected by mammography), lambda2 (transition rate from preclinical screen-detectable phase to clinical phase) and mi (incidence of overdiagnosed tumours) was performed. Estimation procedure was performed using Bayesian methods implemented in WinBUGS software. Results: The incidence of overdiagnosed tumours was from 3 x 10-6 till 9 x 10-6 according to age group examined and was slightly higher for older women. Conclusion: Overdiagnosis doesn’t seem to be significant problem in organized breast cancer screening programme in the Czech Republic. |