Ovlivnění buněčných linií A2780 a A2780cis v závislosti na aplikaci ultrazvukového pole a cytostatika
| Title in English | Effect of cell line A2780 and A2780cis depending on the application of ultrasonic fields and cytostatics |
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| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Folia Medica Cassoviensia |
| MU Faculty or unit | |
| Citation | |
| Field | Biophysics |
| Keywords | cisplatin; ovarian cells; viability |
| Description | The study aims to publish partly results of the in vitro experiments of low-power ultrasound, the anti-cancer drug cisplatin, and their combined application. The effects of the viability changes were studied in two lines of human ovarian carcinoma cells, A2780 and cisplatin resistant A2780cis. Experimental groups were used: exposure to ultrasonic field, application of cisplatin, exposure to ultrasound followed by cisplatin, and presence of ciplatin followed by exposure to application ultrasound. Ultrasound far field was used at intensities of 1.5 W/cm2 for 10 min exposure; cisplatin was applied at concentrations of IC50. The results suggestive to that a combined effect of ultrasound and cisplatin was more effective than that of ultrasound or cisplatin alone. |