Nuclear topography of the 1q21 genomic region and Mcl-1 protein levels associated with pathophysiology of multiple myeloma

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Authors	LEGARTOVÁ Soňa KREJČÍ Jana HARNIČAROVÁ Andrea HÁJEK Roman KOZUBEK Stanislav BÁRTOVÁ Eva
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Neoplasma
MU Faculty or unit	Faculty of Science
Citation
Field	Oncology and hematology
Keywords	multiple myeloma; 1q21; DNA-FISH
Description	Karyotypic abnormalities seen in MM cells correlate with the disease stage and drug responses. Here, we investigate the nuclear arrangement of the 1q21 region; amplification of this region is an important diagnostic and prognostic marker of MM. We examined the lymphoblastoid cell line CD138- ARH-77, multiple myeloma CD138+ MOLP-8 cells, and the CD138+ bone marrow fraction of patients diagnosed with MM.