YEAST: AN APPROPRIATE MODEL FOR THE DETECTION OF CANCEROSTATICS
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Proceedings |
| Conference | 37th Annual Conference on Yeasts. |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Yeast Cell - cytostatics - cell cycle - mitosis - nuclear division - microtubular cytoskeleton - actin filaments - calmodulin - cell senescence |
| Description | Three selected yeast strains of Yarrowia lipolytica species were used as modelling objects to test 62 chemical substances considered to be potentional cytostatics. In the cells following phenomena were observed and analysed: 1/ process of cell cycle, 2/ process of mitosis, 3/ morphology of nucleus, formation of polynuclear forms, 3/ amount of DNA in nucleus, polyploid nuclei formation, 4/ localization, morphology of microtubular cytoskeleton, 5/ amount and localization of actin microfilaments, 6/ presence, amount and localization of calmodulin. Six of all analysed substances were found to be appropriate (as cytostatics) and were suggested for a further detailed analysis. |
| Related projects: |