MicroRNA-malé molekuly s velkým významem (nejen) u hematologických malignit
| Title in English | MicroRNA - small molecules with major role (not only) in hematological malignancies |
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| Authors | |
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Transfuze a hematologie dnes |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | microRNA; miRNA; RNAinterference; regulation of gene expression; CLL-chronic lymphocytic leukemia |
| Description | MicroRNAs are small molecules of ribonucleic acid playing important roles in the regulation of gene expression. Their function is based on the mechanism of RNA interference that enables specific gene silencing on the post-transcriptional level. About 750 microRNA genes have been already found in the humane genome. However, this number is not final as the computational analyses predict an existence of at least thousand human microRNAs. It has been presumed that microRNAs regulate the expression of one third of protein-coding genes, documenting their crucial role in a cell and cell cycle progression. Deregulation of miRNA has been described in the majority of cancers including hematological malignancies. There is growing evidence that aberrant miRNA expression could participate in the process of malignant transformation of a cell. A direct role in the pathogenesis of a disease has been described in many hematological malignancies. Deletion of miR-15a and miR-16-1, which regulate expression of BCL2 oncogene, detected in approximately 50 % patients with B-cell chronic lymphocytic leukemia can serve as an example. |