Computer modelling in cardiac cell electrophysiology

Authors

PÁSEK Michal

Year of publication 2007
Type Article in Periodical
Magazine / Source Engineering Mechanics.
MU Faculty or unit

Faculty of Medicine

Citation
Field Biophysics
Keywords electrophysiology; cardiac cell; quantitative modelling
Description Experimentally based models of cardiac cells have been developed since 1960. The early models were based on extension of the Hodgkin-Huxley nerve impulse equations. Including only a few membrane currents they were able to successfully reconstruct the depolarization and repolarization of cellular membrane. Since that time, the models have underwent extensive modifications and reached a high degree of physiological detail. This short review is aimed to outline the history of their development and show the importance of computer modelling for the research in cardiac cell electrophysiology.

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