Porucha barvocitu u alkoholiků a její souvislost s polymorfizmem genu pro BDNF
| Title in English | Color vision deficiency in alcoholics and its relationship with the BDNF polymorphism |
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| Authors | |
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | alcoholism BDNF retina vision color apoptosis GABA |
| Description | The alcoholism induces the brain damage but also it may cause the color vision deficiency. In our association study of genetic dispositions to the alcoholism on 167 alcoholics and 289 non-alcoholic controls, we studied a relationship between candidate genes and alcoholism. In all subjects involved in this study many factors, e.g. color vision deficiencies, were tried. Surprisingly, after the statistical analysis, we found that 47,9% of alcoholics have problems with color vision deficiency and moreover that this color vision deficiency is in the relationship with the polymorphism of BDNF (Brain-derived neurotrophic factor) gene. It is well known that BDNF plays a role in the neurodevelopment of retina and in the protection of photoreceptors from apoptosis. Potential role of BDNF gene in the color vision deficiency in alcoholics is discussed. |
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