Význam genotypu a fenotypu CYP2D6 při léčbě paroxetinem
| Title in English | Impact of genotype and phenotype CYP2D6 in paroxetine treatment |
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| Authors | |
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Psychiatrie časopis pro moderní psychiatrii |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | genotype-phenotype-CYP2D6-paroxetine-sexual dysfunction |
| Description | The aim of study was comparison of distribution of therapeutic efficacy and side effects including sexual dysfunction in long term paroxetine treatment within 50 patients genotyped and phenotyped to determine their CYP2D6 metabolic status.No variation in therapeutic efficaccy and common adverse effects between subjects classified as PM and those marked as EM was found. A significantly higher rate of sexual dysfunction was recorded among patients with a PM phenotype. |
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