Individualizace farmakoterapie inhibitory tymidylát syntázy u nádorů gastrointestinálního traktu
| Title in English | The individualised pharmacotherapy of gastrointestinal cancer bases on thymidylate synthase inhibitors |
|---|---|
| Authors | |
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Klinická farmakologie a farmacie |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.klinickafarmakologie.cz/artkey/far-200403-0006.php |
| Field | Oncology and hematology |
| Keywords | tymidylát syntáza; fluoropyrimidinové deriváty; antifoláty; komplexní profily genové expresew |
| Description | The inhibitors of thymidylate synthase (TS) are frequently used as anticancer drugs. These drugs can be divided into two principal groups: the fluoropyrimidine derivatives and folic acid analogs. All these inhibitors change enzymatic activity of TS, and at the same time they are also metabolizeded by different enzymes. The interindividual differences in the expression and activity of TS and of other enzymes can be exploited in the design of targeted individual anticancer therapy. Unfortunately the drug resistance is influenced by hundreds of genes. If we would like to predict the drug resistance, the determination of as little as several markers would not be probably efficient. The routine establishment of methods of screening expression of tens or hundreds of genes and their protein products will be probably necessary for such prediction. |