Architektonika descendentních spojů sluchové dráhy a její možný význam v patogenezi tinnitu
| Title in English | Architecture of Descendent Connections of the Auditory Pathway and Its Possible Role In Pathogenesis of Tinnitus |
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| Authors | |
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Otolaryngologie a foniatrie |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.clsjep.cz/Ukazclanek2.asp?clanek=18623&jazyk=&cislo=1151 |
| Field | ORL, ophthalmology, stomatology |
| Keywords | tinnitus; pathogenesis; descendent connetions; auditory pathway |
| Description | Tinnitus may be defined as a clinical correlation of spontaneous neural activity of the auditory pathway in conditions responsible for absent stimuli in the cases of affected tonotopy. The contribution suggests a disinhibition hypothesis for the pathogenesis of tinnitus based on a feedback regulation of neural transfer of auditory pathway, where de-afferentation results in hyperexcitation in the region of presynaptic nerve endings, and thereby to alternative activation of ascendant NMDA synapses. In the pathogenesis of tinnitus we presume a combined action of inhibiting facilitation connections for the presynaptic membrane; moreover, we suppose the stress to be a decisive factor in the origin of chronic tinnitus. The authors also discuss efficiency in the treatment of tinnitus related to disinhibition hypothesis and possibilities of closer specification of the system responsible for pathogenesis of tinnitus. |