Geny pro Il-6 a DRD2 souvisejí s hyperkinetickou poruchou
| Title in English | IL-6 and DRD2 genes are associated with ADHD |
|---|---|
| Authors | |
| Year of publication | 2003 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | ADHD; IL-6; DRD2; association study; polymorphism |
| Description | TaqI A polymorphism of the dopamine receptor D2 gene (DRD2) was previously associated with ADHD, alcoholism, drug dependence etc. -174 polymorphism of interleukin-6 (IL-6) gene was associated with alcoholism. In our association study, we studied the difference in genotype and allelic frequencies of polymorphisms above mentioned between boys with ADHD and boys in control group. Buccal tissue was used for isolation of genomic DNA using commercial kit UltraClean Tissue DNA (MoBio, USA). PCR with subsequent restriction analysis was used for determination of genotypes. Genotype and allelic frequency of TaqI A polymorphism of DRD2 gene was statistically different between ADHD group and control group (p < 0,04 and p < 0,002, respectively), as well as genotype and allelic frequency of -174 polymorphism of IL-6 was statistically different between studied groups of boys (p < 0,004 and p < 0,001, respectively). Our study confirmed the association found previously between TaqI A polymorphism and ADHD and provided new data about the first discovered association between -174 polymorphism of IL-6 gene and ADHD. |
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