Activation of p53 protein to sequence-specific DNA binding by its phosphorylation
| Authors | |
|---|---|
| Year of publication | 2001 |
| Type | Article in Periodical |
| Magazine / Source | European Journal of Biochemistry |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Description | Protein p53 seems to be one of the most important tummor suppressor proteins. The DNA binding function is cryptic and can be activated by different stimuli modulating C-terminal domain. The most likely physiological mechanism of p53 activation is posttranslational modification, mainly phosphorylation of specific sites. |
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