A preliminary choroid plexus volumetric study in individuals with psychosis

Authors

SENAY Olcay SEETHALER Magdalena MAKRIS Nikos YETERIAN Edward RUSHMORE Jarrett CHO Kang Ik K RIZZONI Elizabeth HELLER Carina PASTERNAK Ofer SZCZEPANKIEWICZ Filip WESTIN Carl-Frederik LOŠÁK Jan USTOHAL Libor TOMANDL Josef VOJTÍŠEK Lubomír KUDLIČKA Petr KIKINIS Zora HOLT Daphne LEWANDOWSKI Kathryn E LIZANO Paulo KESHAVAN Matcheri S ONGUR Dost KAŠPÁREK Tomáš BREIER Alan SHENTON Martha E SEITZ-HOLLAND Johanna KUBICKI Marek

Year of publication 2023
Type Article in Periodical
Magazine / Source Human Brain mapping
MU Faculty or unit

Faculty of Medicine

Citation
Web https://onlinelibrary.wiley.com/doi/10.1002/hbm.26224
Doi http://dx.doi.org/10.1002/hbm.26224
Keywords cerebrospinal fluid; manual segmentation; neuroinflammation; perivascular space; schizophrenia; ventricle
Description The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p < .00010, right: p < .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p < .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.

You are running an old browser version. We recommend updating your browser to its latest version.

More info