Insufícience růstového hormonu u dospělých a inzulínová senzitivita
| Title in English | Growth hormone insufficiency in adults and insulin sensitivity |
|---|---|
| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Postgraduální medicína |
| MU Faculty or unit | |
| Citation | |
| Field | Endocrinology, diabetology, metabolism, nutrition |
| Keywords | growth hormone; glucose homeostasis; insulin sensitivity |
| Description | Growth hormone is a polypeptide produced by adenohypo-physis. It is a crucial influence in children's growth and it also has many other effects, mostly metabolic. In adult age, its insufficient levels manifest in abnormal body composition, with excess body fat, and lower volume of muscle and bone mass, along with lowered muscle effectiveness, psychological changes and generally a lower quality of life. An aspect of this mostly metabolic syndrome are adverse changes to the lipid spectrum and reduced insulin sensitivity. Patients with CHD often have an impacted glucose metabolism, with increased insulin resistance, lowered function of pancreatic beta cells and increased volume of fat tissue. CH substitution with daily subcutaneous application can influence the metabolic system by changes to glucose homeostasis, improved lipid metabolism, reduction of fat tissue and increase of non-fat tissues and improved mineralisation of bone mass. Changes in body composition seem to be important in the changes to glucose homeostasis in adult patients with CHD. CH substitution treatment does not, in adequate doses, increase the risk of diabetes, restoring instead natural physiological conditions and leads to improved or corrected clinical condition in these patients |