Expression of VEGF-A by neoplastic cells in T-cell lymphoblastic lymphoma: possible therapeutic implications related to immunomodulatory properties of this cytokine
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| Year of publication | 2015 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Background: VEGF-A, well known for its mechanistic angiogenic effect and as a target for antiangiogenic therapeutic drugs, has also potent immunomodulatory characteristics. Namely, it contributes to blockade of dendritic cells maturation and increases a number of regulatory T lymphocytes (Treg’s) in blood and tumor tissues. Conclusion: We found expression of VEGF-A in a majority of cases of T-LL. Because of known immunosuppressive properties of VEGFA, possible adding of antiangiogenic drugs to therapeutic armamentarium in T-LL appears warranted. |