Outcomes of 167 healthy sibling donors after peripheral blood stem cell mobilization with G-CSF 16 mu g/kg/day: efficacy and safety
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Neoplasma |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.4149/neo_2015_094 |
| Field | Oncology and hematology |
| Keywords | sibling donor; PBSC mobilization; G-CSF |
| Description | Mobilization of peripheral blood stem cells (PBSC) using the granulocyte colony-stimulating factor (G-CSF) has enabled the collection even from older donors and those with comorbidities. Several clinical parameters have been reported to predict the success of PBSC mobilization. The aim of our study was to evaluate the safety of PBSC donation in a cohort of 167 sibling donors after mobilization with G-CSF 16 mu g/kg/day for 5 days during short- and long term follow-up and to analyse the efficacy, toxicity and factors influencing CD34+ mobilization capacity. All 167 sibling donors completed the established mobilization protocol. The median yield was 7.9x10(6)CD34 cells/kg per recipient weight. The optimal target dose of CD34 cells >= 4.0x10(6)/kg was achieved in 140 donors (84%). Only in 4 donors (2%) was the CD34+ yield < 2x10(6)/kg. No major toxicities occured. Factors associated with higher PBSC yields included age < 55 years (p=0.001), male gender (p=0.004), preapheresis CD34 cell counts > 51/mu L (p < 0.001) and preapheresis leukocyte counts >45.5 x 10(9)/L (p =0.003). Comorbidity score, performance status and donor weight did not significantly influence PBSC yields. Long-term follow-up was possible in 60% (101/167) of the donors. The median length of follow-up from PBSC donation was 11.9 years. Most of these donors reported good or very good general health (91%), and no hematological malignancies were observed. The mobilization of PBSC in sibling donors with G-CSF 16 mu g/kg/day is an effective and safe procedure with no significant short- and long-term toxicities. |