A significant number of studies describe that cell deformability is potential important diagnostic predictor of tumor aggressiveness. However, the current cell-deformation-analyzing methods are limited by low robustness or the need for expert operation thus limiting clinical introduction. Still, the advances in quantitative phase imaging (QPI) have made it possible to extract physical parameters from microscopic images of living cells. We demonstrated QPI is valuable just for the detection of cell deformation with much higher robustness and ease of use. In the following, the aim is to test the practical aspects of this experimental conclusion.

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