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Project information
Identification and characterization of proteins involved in metabolism of G-quadruplexes and R-loops and molecular mechanisms of their relationship with replication

Project Identification
21-22593X
Project Period
1/2021 - 12/2025
Investor / Pogramme / Project type
Czech Science Foundation
  • EXPRO
MU Faculty or unit
Faculty of Medicine
Cooperating Organization
Institute of Molecular Genetics of the ASCR, v. v. i.
  • Responsible person Mgr. Jana Dobrovolná, Ph.D.

DNA replication is an essential and one of the most complex processes in the cell. Not only exogenous DNA damage but also intrinsic DNA structures including G-quadruplexes (G4) and R-loops, their stabilization or unscheduled formation represent major replication obstacles with possible detrimental effects on genome integrity. Not surprisingly, those processes are pharmacologically targeted in anticancer therapy, despite the fact that only little is known about the underlying molecular mechanisms. It becomes apparent that maintenance of processive DNA replication requires sophisticated protein networks beyond the core replisome. Whether there is a direct crosstalk between G4 and R-loops, what proteins are involved in their homeostasis and what are the factors diversifying between their beneficial and pathological roles, is not well understood. The goals of our research are to identify proteins associated with G4 and R-loop structures and understand their roles in G4/R-loop formation and resolution as well as relationship to replication fork progression and associated repair.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No. 3 – Good health and well-being Sustainable Development Goal No. 5 – Gender equality Sustainable Development Goal No. 17 – Partnerships for the goals

Publications

Total number of publications: 9

2024

2023

2022

2021

2020

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