Project information
Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective
(DBS3D)
- Project Identification
- GA21-25953S
- Project Period
- 1/2021 - 12/2023
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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Institute of Scientific Instruments of the ASCR, v. v. i.
- Responsible person Ing. Pavel Jurák, CSc.
The main aim of the project is to study cortico-subcortical interactions via advanced analysis of electrophysiological phenomena from microrecording to the whole brain levels. These interactions are basis for the understanding of the brain’s functioning, particularly in its pathological alterations; To investigate brain electrical activity in diseases involving both cortical and subcortical structures, i.e. with primarily subcortical pathology (Parkinson’s Disease) and primarily cortical pathology (Epilepsy). To identify electrophysiological phenomena related to DBS therapy with the main focus on possible predictive biomarkers. To follow up our pilot data defining optimal and suboptimal response to DBS in a long-term neuropsychological observation.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 13
2024
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Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS
NPJ PARKINSONS DISEASE, year: 2024, volume: 10, edition: 1, DOI
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Topological network analysis of human brain function
Year: 2024, type: Appeared in Conference without Proceedings
2023
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Relative entropy is an easy-to-use invasive electroencephalographic biomarker of the epileptogenic zone
Epilepsia, year: 2023, volume: 64, edition: 4, DOI
2022
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Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy
Clinical Neurophysiology, year: 2022, volume: 144, edition: December 2022, DOI
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Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae
Journal of Neural Transmission, year: 2022, volume: 129, edition: 8, DOI
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Subkortiko-kortikální funkční vztahy lidského mozku během kognitivní zátěže
Year: 2022, type: Appeared in Conference without Proceedings
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The reduction of hippocampal volume in Parkinson's disease
Journal of Neural Transmission, year: 2022, volume: 129, edition: 5-6, DOI
2021
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Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease
Human Brain mapping, year: 2021, volume: 42, edition: 17, DOI
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Electrophysiological biomarkers for deep brain stimulation outcomes in movement disorders: state of the art and future challenges
Journal of Neural Transmission, year: 2021, volume: 128, edition: 8, DOI
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Ictal connectivity changes induced by pulvinar stimulation correlate with improvement of awareness
Year: 2021, type: Article in Periodical (without peer review)