Project information
Protein Affinity and Selectivity to Cellular Membranes

Information

This project doesn't include Faculty of Medicine. It includes Central European Institute of Technology. Official project website can be found on muni.cz.

Project Identification

GA20-20152S

Project Period

1/2020 - 12/2022

Investor / Pogramme / Project type

Czech Science Foundation

Standard Projects

MU Faculty or unit

Central European Institute of Technology

prof. RNDr. Robert Vácha, PhD.

The aim of the proposed challenging project is to develop a new method, using which we will
elucidate the relationship between protein sequence and preferred composition and curvature
of human membranes.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Publications

Total number of publications: 11

2023

Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase

JAHN Helene BARTOŠ Ladislav DEARDEN Grace I. DITTMAN Jeremy S. HOLTHUIS Joost C. M VÁCHA Robert MENON Anant K.

Article in Periodical

Nature Communications, year: 2023, volume: 14, edition: 1, DOI

2022

Binding of DEP domain to phospholipid membranes: More than just electrostatics

FALGINELLA Francesco Luca KRAVEC Marek DRABINOVÁ Martina PACLÍKOVÁ Petra BRYJA Vítězslav VÁCHA Robert

Article in Periodical

Biochimica et Biophysica Acta (BBA) - Biomembranes, year: 2022, volume: 1864, edition: 10, DOI
Magainin 2 and PGLa in Bacterial Membrane Mimics III: Membrane Fusion and Disruption.

KABELKA Ivo GEORGIEV Vasil MARX Lisa PAJTINKA Peter LOHNER Karl PABST Georg DIMOVA Rumiana VÁCHA Robert

Article in Periodical

Biophysical Journal, year: 2022, volume: 121, edition: 5, DOI
Magainin 2 and PGLa in bacterial membrane mimics IV: Membrane curvature and partitioning

SEMERARO E.F. PAJTINKA Peter MARX L. KABELKA Ivo LEBER R. LOHNER K. VÁCHA Robert PABST G.

Article in Periodical

BIOPHYSICAL JOURNAL, year: 2022, volume: 121, edition: 23, DOI
Synthesis and Profiling of Highly Selective Inhibitors of Methyltransferase DOT1L Based on Carbocyclic C-Nucleosides

KHIRSARIYA PrashantKumar POSPÍŠIL Patrik MAIER Lukáš BOUDNÝ Miroslav BABÁŠ Martin KROUTIL Ondřej MRÁZ Marek VÁCHA Robert PARUCH Kamil

Article in Periodical

Journal of Medicinal Chemistry, year: 2022, volume: 65, edition: 7, DOI

2021

Advances in Molecular Understanding of α-helical Membrane-Active Peptides.

KABELKA Ivo VÁCHA Robert

Article in Periodical

Accounts of chemical research, year: 2021, volume: 54, edition: 9, DOI
Cardiolipin-Containing Lipid Membranes Attract the Bacterial Cell Division Protein DivIVA

LABAJOVA N. BARANOVA N. JURÁSEK Miroslav VÁCHA Robert LOOSE M. BARAK I.

Article in Periodical

International Journal of Molecular Sciences, year: 2021, volume: 22, edition: 15, DOI
Cargo Release from Nonenveloped Viruses and Virus-like Nanoparticles: Capsid Rupture or Pore Formation

SUKENÍK Lukáš MUKHAMEDOVA Liya PROCHÁZKOVÁ Michaela ŠKUBNÍK Karel PLEVKA Pavel VÁCHA Robert

Article in Periodical

ACS Nano, year: 2021, volume: 15, edition: 12, DOI
Enhanced translocation of amphiphilic peptides across membranes by transmembrane proteins.

BARTOŠ Ladislav KABELKA Ivo VÁCHA Robert

Article in Periodical

Biophysical Journal, year: 2021, volume: 120, edition: 11, DOI
Selecting Collective Variables and Free Energy Methods for Peptide Translocation Across Membranes.

KABELKA Ivo BROŽEK Radim VÁCHA Robert

Article in Periodical

Journal of Chemical Information and Modeling, year: 2021, volume: 61, edition: 2, DOI