Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1210
2011
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c-Myb regulates MMP1, MMP9 and cathepsin D: Implications for the matrix-dependent breast cancer cell invasion and metastasis
Year: 2011, type: Conference abstract
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c-Myb-induced migration/invasiveness of breast and colon cells in vitro is not associated with enhanced lung colonization in vivo
Year: 2011, type: Conference abstract
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Colicin FY – a novel bacteriocin of Yersinia frederiksenii.
Year: 2011, type: Conference abstract
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Comparison of multiplex PCRs, (GTG)5-PCR and automated ribotyping for identification of Lactobacillus spp. isolated from children's intestinal tissues.
Year: 2011, type: Conference abstract
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Competitive canalization of PIN-dependent auxin flow from axillary buds controls pea bud outgrowth
The Plant Journal, year: 2011, volume: 65, edition: 4, DOI
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Congenital Myotonia Caused by Mutations in the CIC-1 Chloride Channel Gene
Ceska a slovenska neurologie a neurochirurgie, year: 2011, volume: 74, edition: 4
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Cracking the chromatin code: Precise rule of nucleosome positioning
PHYSICS OF LIFE REVIEWS, year: 2011, volume: 8, edition: 1, DOI
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C-terminal extension of telomerases: structural and functional analysis
Year: 2011, type: Appeared in Conference without Proceedings
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Cytogenetic studies in vegetable Brassicas
Genetics, Genomics and Breeding of Vegetable Brassicas, year: 2011, number of pages: 46 s.
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Cytokinin and Auxin Interactions in Plant Development: Metabolism, Signalling, Transport and Gene Expression
CURRENT PROTEIN & PEPTIDE SCIENCE, year: 2011, volume: 12, edition: 2