Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1210
2010
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Identifikácia receptoru nového kolicínu FY.
Year: 2010, type: Conference abstract
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Impact of Chromosomal Abnormalities and Gain of 1q21 in Multile Myeloma
Year: 2010, type: Conference abstract
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Incidence of bacteriocin types among human commensal and pathogenic E. coli strains.
Year: 2010, type: Conference abstract
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Influence of DNA methylation on telomeric repeats in plant models
Year: 2010, type: Conference abstract
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Influence of LOX/COX inhibitors on cell differentiation induced by all-trans retinoic acid in neuroblastoma cell lines.
International Journal of Molecular Medicine, year: 2010, volume: 25, edition: 2
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Island species radiation and karyotypic stasis in Pachycladon allopolyploids
BMC Evolutionary Biology, year: 2010, volume: 2010, edition: 10
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Keratin mutations in patients with epidermolysis bullosa simplex: correlations between phenotype severity and disturbance of intermediate filament molecular structure
The British journal of dermatology : the official organ of the British Association of Dermatology, year: 2010, volume: 162, edition: .
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Klonování a exprese lytických genů polyvalentního stafylokokového bakteriofága
25. kongres Československej spoločnosti mikrobiologickej „MIKROORGANIZMY A KVALITA ŽIVOTA“, year: 2010
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Lactic Acid Bacteria Classification by MALDI MS
Year: 2010, type: Conference abstract
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LC with off-line MALDI mass spectrometry for analysis of bioactive compounds
X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků, year: 2010