Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1210
2005
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Jak vznikají nádory?
Universitas, year: 2005, volume: 38, edition: 4
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Komparatívna genómová hybridizácia s vyšším rozlišením a jej využitie pro diagnostiku a liečbu onkologických pacientov.
Študenská vedecká konferencia - zborník príspevkov z prednášok a posterov, year: 2005
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Komparativní genomika Treponema pallidum technikou genomové hybridizace na oligonukleotidovém čipu.
Year: 2005, type: Conference abstract
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Mapování genomů patogenních spirochet.
Sborník příspěvků IX. Pracovního setkání biochemiků a molekulárních biologů, year: 2005
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Minisatellite telomeres in the family Alliaceae are lost with divergence of the genus Allium
Year: 2005, type: Conference abstract
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Molecular analysis of FRI (FRIGIDA) gene in early and late-flowering ecotypes and late-flowering mutants in Arabidopsis thaliana.
From laboratory to business, year: 2005
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Molecular mapping of some Arabidopsis thaliana genes determining leaf shape and chlorophyll defects.
Biologia, Bratislava, year: 2005, volume: 60, edition: 4
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Molecular recognition of colicin U and Y pore-forming domains by their cognate immunity proteins.
Year: 2005, type: Conference abstract
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Molekulární interakce kolicinu U se svým imunitním proteinem.
Chemické listy 99, year: 2005
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Molekulární interakce mezi kolicinem U a jeho imunitním proteinem.
Sborník příspěvků IX. Pracovního setkání biochemiků a molekulárních biologů, year: 2005