Project information
Advanced sequencing methods for deciphering structural variants in cancer genome
- Project Identification
- NU21-08-00237
- Project Period
- 5/2021 - 12/2025
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- Ministry of Health Research Programme 2020 - 2026
- Subprogram 1 - standard
- MU Faculty or unit
- Central European Institute of Technology
- Cooperating Organization
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University Hospital Brno-Bohunice
Moderní metody sekvenování DNA umožňují podrobné mapování nádorového genomu a identifikaci lézí, na něž je možné cílit protinádorovou léčbu. Sekvenování pomocí dlouhého čtení dovoluje charakterizovat přestavby genomu, které je obtížné přesně určit pomocí standardních metod nádorové cytogenetiky. Ve skupině pacientů s hematoonkologickými diagnózami chceme využít nové sekvenační metody pro zjištění organizace genomu a rekurentních přestaveb s cílem pochopit mechanismy vzniku aberací a určit jejich význam pro klinický průběh nemoci a odpověď na léčbu.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 36
2024
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The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia
Leukemia, year: 2024, DOI
2023
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A web-based bioinformatic tool LYNX for targeted LYmphoid NeXt- generation sequencing data analysis and visualization for hematooncology.
Year: 2023, type: Conference abstract
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Application of long-read sequencing for detection of complex chromosomal rearrangements.
Year: 2023, type: Conference abstract
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Application of long-read sequencing in chronic lymphocytic leukemia cases with complex karyotype.
Year: 2023, type: Conference abstract
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CLLue: Searching for connections among clinical, biological, and molecular features in the dataset of leukemia patients.
Year: 2023, type: Conference abstract
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Clonal competition and disrupted molecular processes in chronic lymphocytic leukemia.
Year: 2023, type: Conference abstract
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Exploring patterns in clinical, biological, and molecular data of leukemia patients with CLLue.
Year: 2023, type: Conference abstract
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Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia.
Year: 2023, type: Conference abstract
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Resolving chromatin organization in chronic lymphocytic leukemia.
Year: 2023, type: Conference abstract
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Solving complex karyotypes in leukemia samples using long-read sequencing.
Year: 2023, type: Conference abstract