The association between high-activity COMT allele and alcoholism

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Authors

ŠERÝ Omar MIKEŠ Vladimír PITELOVÁ Renáta ZNOJIL Vladimír ZVOLSKÝ Petr

Year of publication 2006
Type Article in Periodical
Magazine / Source Neuroendocrinology Letters
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords alcohol dependence; association; COMT; Val158Met polymorphism; gene
Description Objectives: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline. The Val158Met polymorphism of the COMT gene has been previously associated with a variability of the COMT activity, and alcoholism. The aim of the present association study was to examine the relationship between the Val158Met polymorphism of the COMT gene and dispositions to alcoholism. Methods: In our case control study we analyzed DNA samples from 799 subjects in total (279 male alcoholics and 120 female alcoholics, 151 male controls and 249 female controls). The restriction analysis for the detection of the Val158Met polymorphism was used. Results: We found a relationship between the Val158Met polymorphism of the COMT gene and alcoholism in male subjects. We found the significant difference between male alcoholics and male controls in allele and genotype frequencies (p<0,007; and p<0,04 respectively). Conclusions: Our study confirmed the relationship between the COMT polymorphism and alcoholism in the Czech male population.
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