Metabolic Syndrome Prevalence in Women with Gestational Diabetes Mellitus in the Second Trimester of Gravidity

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Authors

BARTÁKOVÁ Vendula CHALÁSOVÁ Katarína PÁCAL Lukáš ŤÁPALOVÁ Veronika MÁCHAL Jan JANKŮ Petr KAŇKOVÁ Kateřina

Year of publication 2024
Type Article in Periodical
Magazine / Source JOURNAL OF CLINICAL MEDICINE
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.mdpi.com/2077-0383/13/5/1260
Doi http://dx.doi.org/10.3390/jcm13051260
Keywords gestational diabetes; metabolic syndrome; pregnancy; obesity
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Description Background: Women with gestational diabetes (GDM) have an increased risk of metabolic syndrome (MS) after delivery. MS could precede gravidity. The aims of this study were (i) to detect the prevalence of MS in women at the time of GDM diagnosis, (ii) to detect the prevalence of MS in the subgroup of GDM patients with any form of impaired glucose tolerance after delivery (PGI), and (iii) to determine whether GDM women with MS have a higher risk of peripartal adverse outcomes. Methods: A cross-sectional observational study comprised n = 455 women with GDM. International Diabetes Federation (IDF) criteria for MS definition were modified to the pregnancy situation. Results: MS was detected in 22.6% of GDM patients in those with PGI 40%. The presence of MS in GDM patients was associated with two peripartal outcomes: higher incidence of pathologic Apgar score and macrosomia (p = 0.01 resp. p = 0.0004, chi-square). Conclusions: The presence of MS in GDM patients is a statistically significant risk factor (p = 0.04 chi-square) for PGI. A strong clinical implication of our findings might be to include MS diagnostics within GDM screening using modified MS criteria in the second trimester of pregnancy.
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