Kinetic Study of Metal Complexes with Tetraazamacrocyclic Ligands with Carboxylate/Phosphonate Pendant Arms
| Authors | |
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| Year of publication | 2012 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Ln(III) and Cu(II) complexes are utilized in medicine and preclinical research as magnetic resonance, optical or nuclear probes for diagnostics and/or for cancer treatment. For biomedical applications, such complexes should exhibit a high thermodynamic stability as well as kinetic inertness under physiological conditions. Thus, knowledge of their thermodynamic/kinetic properties (e.g. dissociation rate constants for an estimation of kinetic inertness) is important to evaluate their use in these applications. Here, thermodynamic and kinetic properties of Cu(II), Ce(III) and Eu(III) complexes with macrocyclic cyclen-based ligands where acetate pendant arms were substituted by phosphonates (H4dota, H5do3ap, trans-H6do2a2p, H7doa3p, H8dotp) [1–4] are presented. In addition, the influence of substitution of one acetate/phosphonate of (H2do2a/H3do3a/H4dota/H5do3ap derivatives) and/or all phosphonate pendant arms (H8dotp derivatives) was also studied [5-7]. These results show that the kinetic inertness of the metal complexes is influenced by these substitutions and, therefore, this fact should be taken into account in possible in vivo applications of the ligands/complexes. |
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