Informace o projektu
Zdravé stárnutí mozku: Celoživotní perspektiva
- Kód projektu
- NU20J-04-00022
- Období řešení
- 5/2020 - 12/2023
- Investor / Programový rámec / typ projektu
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Ministerstvo zdravotnictví ČR
- Program na podporu zdravotnického aplikovaného výzkumu na léta 2020 - 2026
- Podprogram 2 - juniorský - výzkumníci do 35 let
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Národní ústav duševního zdraví
- Odpovědná osoba MUDr. Pavla Čermáková, Ph.D.
Brain disorders, such as cognitive impairment and depression, are the strongest contributors to disability in older adults, but the developmental origins of these disorders are still not very well understood. Within this project, we aim to take a life-course perspective and study the role of biological aging on vulnerability to cognitive and affective disorders. In work package 1, we will analyze longitudinal data on cognitive performance and depression from the Czech arm of the study Health, Alcohol and Psychosocial factors In Eastern Europe (HAPIEE; n=8 856 individuals, aged 58 years at baseline in 2002, 53% women). Since recent studies suggest that alterations in the brain, previously believed to occur only in later life, are present already in young adults before they reach their 30th birthday, work package 2 of the current project will invite members of the prenatal birth cohort from European Longitudinal Study of Pregnancy and Childhood (ELSPAC) who took part in its neuroimaging follow-up in 2015 (n=131; age 23-24; 53% women) to a second neuroimaging follow-up (age 28-29) and assess their DNA epigenetic age, biological age, cardiovascular risk factors, cognition, mood and anxiety. This will allow us to elucidate the impact of biological aging on trajectories of brain function in young adulthood and propose interventions to decrease the burden of brain disorders.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 14
2022
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Socioeconomic and cognitive roots of trait anxiety in young adults
Social Cognitive and Affective Neuroscience, rok: 2022, ročník: 17, vydání: 8, DOI
2021
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Cognitive impairment and depression: Meta-analysis of structural magnetic resonance imaging studies
NeuroImage: Clinical, rok: 2021, ročník: 32, vydání: 2021, DOI
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Sex differences in the association of childhood socioeconomic position and later-life depressive symptoms in Europe: the mediating effect of education
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY, rok: 2021, ročník: 56, vydání: 6, DOI
2020
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Epigenetic clock as a correlate of anxiety
NeuroImage, rok: 2020, ročník: 28, vydání: 2020, DOI