Informace o projektu
Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
- Kód projektu
- VS96097
- Období řešení
- 7/1996 - 12/2000
- Investor / Programový rámec / typ projektu
-
Ministerstvo školství, mládeže a tělovýchovy ČR
- Posílení výzkumu na vysokých školách
- Fakulta / Pracoviště MU
- Lékařská fakulta
An extensive study is realized in the framework of the VS 96 097 grant on the expected association between the allelic variants of selected candidate genes with several multigenic common diseases, possibly with their intermediate phenotypes.A "case-control" study research strategy is based on population studies of the genetic polymorphisms of selected candidate genes and the search of the temptative associations of the allelic frequencies with some common "civilization" diseases,as essential hypertension, diabetes mellitus (late complications thereof), atopic diseases and with the propensity of malignant tumors to form metastases. The associations are tested by means of multivariational statistical methods.It can be expected that discovering of genetically profiled subsets of patients will enable to achieve more focused prevention and treatment of the disease studied.
Publikace
Počet publikací: 74
1997
-
Age-dependent allelic frequencies of the angiotensin-converting enzyme (ACE) gene
Journal of Molecular Medicine, rok: 1997, ročník: 75, vydání: 5
-
Angiotensin I-converting enzyme (ACE): a review of I/D polymorphism in the world populations
Scripta medica, rok: 1997, ročník: 70, vydání: 2-3
-
Apoptotic damage of DNA in human leukaemic HL-60 cells treated with C2-ceramide was detected after G1 blockage of the cell cycle
Physiological Research, rok: 1997, ročník: 46, vydání: 2
-
Emotional load and 24-h blood pressure monitoring
Homeostasis, rok: 1997, ročník: 38, vydání: 3