Publications

SELECTED RECENT PAPERS:

• Pásek M, Bébarová M, Šimurdová M, Šimurda J. Functional consequences of changes in the distribution of Ca2+ extrusion pathways between t-tubular and surface membranes in a model of human ventricular cardiomyocyte. J Mol Cell Cardiol 2024; 193: 113-124.
• Lietava S, Sepsi M, Zidkova J, Synkova I, Kozak M, Krivan L, Vlasinova J, Richter S, Rehor J, Kala P, Bebarova M, Novotny T. The yield of a comprehensive investigation protocol for the diagnosis of true idiopathic ventricular fibrillation in a real-life clinical setting. Sci Rep 2024; 14: 14089.
• Celiker C, Zelenak S, Lietava S, Pachernik J, Bebarova M, Zidkova J, Novotny T, Barta T. Generation of human induced pluripotent stem cell lines from patients with a RYR2 gene variant c.14201A>G (p.Y4734C): Implications for idiopathic ventricular fibrillation and catecholaminergic polymorphic ventricular tachycardia. Stem Cell Res 2024; 81: 103541.
• Kabanov D, Klimovic S, Beckerová D, Molcan M, Scurek M, Brat K, Bebarova M, Rotrekl V, Pribyl J, Pesl M. Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model. Sci Rep 2024; 14: 27399.
• Iijima A, Švecová O, Hošek J, Kula R, Bébarová M. Sildenafil affects the human Kir2.1 and Kir2.2 channels at clinically relevant concentrations: inhibition potentiated by low Ba²⁺. Front Pharmacol, 2023; 14:1136272.
• Šimurda J, Šimurdová M, Švecová O, Bébarová M. A new approach to the determination of tubular membrane capacitance: passive membrane electrical properties under reduced electrical conductivity of the extracellular solution. Pflugers Arch 2022;474(12):1263-1274.
• Švecová O, Bébarová M, Šimurdová M, Šimurda J. Fraction of the t-tubular membrane as an important parameter in cardiac cellular electrophysiology: a new way of estimation. Front Physiol 2022;13:837239.
• Macháček M, Švecová O, Bébarová M. Combination of sildenafil and Ba²⁺ at a low concentration show a significant synergistic inhibition of inward rectifier potassium current resulting in action potential prolongation. Front Pharmacol 2022;13:829952.
• Klimovic S, Scurek M, Pesl M, Beckerova D, Jelinkova S, Urban T, Kabanov D, Starek Z, Bébarová M, Přibyl J, Rotrekl V, Brat K. Aminophylline induces two types of arrhythmic events in human pluripotent stem cell-derived cardiomyocytes. Front Pharmacol 2022;12:789730.
• Ramalho NJD, Švecová O, Kula R, Šimurdová M, Šimurda J, Bébarová M. Aminophylline at clinically-relevant concentrations affects inward rectifier potassium current in a dual way. Pflugers Arch 2022; 474(3):303-313.
• Synková I, Bébarová M, Andršová I, Chmelikova L, Švecová O, Hošek J, Pásek M, Vít P, Valášková I, Gaillyová R, Navrátil R, Novotný T. Long-QT founder variant T309I-Kv7.1 with dominant negative pattern may predispose delayed afterdepolarizations under β-adrenergic stimulation. Sci Rep 2021;11(1):3573.
• Sutanto H, Cluitmans MJM, Dobrev D, Volders PGA, Bébarová M, Heijman J. Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis: Insights from multiscale in silico analyses. J Mol Cell Cardiol 2020;146:69-83.
• Vaverka J, Moudr J, Lokaj P, Burša J, Pásek M. Impact of Decreased Transmural Conduction Velocity on the Function of the Human Left Ventricle: A Simulation Study. Biomed Res Int 2020;2020:2867865.
• Kula R, Bébarová M, Matejovič P, Šimurda J, Pásek M. Distribution of data in cellular electrophysiology: Is it always normal? Prog Biophys Mol Biol 2020;157:11-17.
• Kula R, Bébarová M, Matejovič P, Šimurda J, Pásek M. Current density as routine parameter for description of ionic membrane current: is it always the best option? Prog Biophys Mol Biol 2020;157:24-32.
• Šimurda J, Šimurdová M, Bébarová M. The intriguing effect of ethanol and nicotine on acetylcholine-sensitive potassium current IKAch: Insight from a quantitative model. PLoS One 2019;14(10):e0223448.
• Policarová M, Novotný T, Bébarová M. Impaired Adrenergic/Protein Kinase A Response of Slow Delayed Rectifier Potassium Channels as a Long QT Syndrome Motif: Importance and Unknowns. Can J Cardiol 2019;35(4):511-522.
• Šimurda J, Šimurdová M, Bébarová M. Inward rectifying potassium currents resolved into components: modeling of complex drug actions. Pflugers Arch 2018;470(2):315-325.
• Vaverka J, Burša J, Šumbera J, Pásek M. Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study. Biomed Res Int 2018;2018:4798512.
• Bébarová M, Matejovič P, Švecová O, Kula R, Šimurdová M, Šimurda J. Nicotine at clinically relevant concentrations affects atrial inward rectifier potassium current sensitive to acetylcholine. Naunyn Schmiedeberg´s Arch Pharmacol 2017;390(5):471-481.
• Radaszkiewicz KA, Sýkorová D, Binó L, Kudová J, Bébarová M, Procházková J, Kotasová H, Kubala L, Pacherník J. The acceleration of cardiomyogenesis in embryonic stem cells in vitro by serum depletion does not increase the number of developed cardiomyocytes. PLoS One 2017;12(3):e0173140.
• Pásek M, Šimurda J, Christé G. Different Densities of Na-Ca Exchange Current in T-Tubular and Surface Membranes and Their Impact on Cellular Activity in a Model of Rat Ventricular Cardiomyocyte. Biomed Res Int 2017;2017:6343821.
• Bébarová M, Hořáková Z, Kula R. Addictive drugs, arrhythmias and cardiac inward rectifiers. Europace 2017;19(3):346-355.