MicroRNAs and their target gene networks in renal cell carcinoma

• Autoři: RÉDOVÁ Martina; SVOBODA Marek; SLABÝ Ondřej
• Rok publikování: 2011
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Biochem Biophys Res Commun
• Fakulta / Pracoviště MU: Středoevropský technologický institut
• www: http://www.sciencedirect.com/science/article/pii/S0006291X11000386
• Doi: http://dx.doi.org/10.1016/j.bbrc.2011.01.019
• Obor: Onkologie a hematologie
• Klíčová slova: MicroRNA; Renal cell carcinoma; Hypoxia; Epithelial-mesenchymal transition; Proliferation; Apoptosis
• Popis: MiRNAs are related to the processes of cell proliferation, apoptosis, angiogenesis, invasion, and metastasis in RCC. MiRNAs expression profiles are associated with several RCC-specific genetic alterations. It has been well documented that several miRNAs are downstream effector molecules of the HIF-induced hypoxia response. MiR-200 family is linked to epithelial-mesenchymal transition which is one of the most significant pathogenetic mechanism in RCC. Mechanistic studies in RCC have provided the rationale of using miRNAs as potential therapeutic targets.

Související projekty

• CEITEC - středoevropský technologický institut