ELECTROCHEMISTRY OF  METALLOTHIONEINS

Varování

Publikace nespadá pod Lékařskou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	ADAM Vojtěch BLAŠTÍK Ondřej FABRIK Ivo ŠOBROVÁ Pavlína PETRLOVÁ Jitka MAJZLÍK Petr TRNKOVÁ Libuše KIZEK René
Rok publikování	2011
Druh	Článek ve sborníku
Konference	XI. Pracovní setkání fyzikálních chemiků a elektrochemiků
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
Obor	Fyzikální chemie a teoretická chemie
Klíčová slova	metallothioneins;cysteine;biosensors;adsorptive transfer stripping technique
Popis	Metallothioneins (MT) are a family of ubiquitous, biologically interesting proteins which have been isolated and studied in a wide variety of organisms, including prokaryotes, plants, invertebrates and vertebrates. Due to the property of MT being metal-inducible and, also, due to their high affinity to metal ions, homeostasis of heavy metal levels is probably their most important biological function. In addition, MT are involved in other important biochemical pathways including scavenging of reactive oxygen species, activation of transcription factors or participation in carcinogenesis. Detection and quantification of MT is not simple due to the high content of cysteine and relatively low molecular mass. These proteins can be detected very sensitively by electrochemical methods. Moreover, MT can be used as a part of biosensors.