MicroRNA involvement in glioblastoma pathogenesis

Název česky Zapojení mikroRNA do patogeneze glioblastomu
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NOVÁKOVÁ Jana SLABÝ Ondřej VYZULA Rostislav MICHÁLEK Jaroslav

Rok publikování 2009
Druh Článek v odborném periodiku
Časopis / Zdroj Biochemical and Biophysical Research Communications
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://www.sciencedirect.com/science/journal/0006291X
Obor Onkologie a hematologie
Klíčová slova MicroRNA; Glioblastoma;Pathogenesis;Apoptosis;Cell cycle
Popis MicroRNAs are endogenously expressed regulatory noncoding RNAs. Altered expression levels of several microRNAs have been observed in glioblastomas. Functions and direct mRNA targets for these microRNAs have been relatively well studied over the last years. According to these data, it is now evident, that impairment of microRNA regulatory network is one of the key mechanisms in glioblastoma pathogenesis. microRNA deregulation is involved in processes such as cell proliferation, apoptosis, cell cycle regulation, invasion, glioma stem cell behavior and angiogenesis. In this review, we summarize the current knowledge of miRNA functions in glioblastoma with an emphasis on its significance in glioblastoma oncogenic signaling and its potential to serve as a disease biomarker and a novel therapeutic target in oncology.

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